Physician Profile

Lawrence G. Raisz, M.D.

Dr. Raisz is one of the preeminent experts in the management of osteoporosis and metabolic bone disease in the world today. Dr. Raisz was one of the founders of the American Society for Bone and Mineral Research, its second president and the founding editor of its journal, the Journal of Bone and Mineral Research. He was scientific editor of the Surgeon General’s Report on Bone Health and Osteoporosis.

At the University of Connecticut, he was the first program director of the Lowell P. Weicker, Jr., General Clinical Research Center and director of the Musculoskeletal Institute. He has been director of the Center for Osteoporosis since its inception in 1990.

At the NIH, he has served on study sections and was chair of the General Medicine B Study Section. Currently he is a member of the advisory council for the National Institutes of Arthritis, Musculoskeletal and Skin Diseases. He is a member of the Board of Trustees of the National Osteoporosis Foundation.

He serves on the editorial boards of 11 journals. He is the author of over 450 publications largely in the field of osteoporosis and metabolic bone disease and co-editor of the major text, “Principles of Clinical Research."

Appointment

• Board of Directors Distinguished Professor of Medicine, UConn Health Center
• Associate Director, New England Musculoskeletal Institute
• Director, University of Connecticut Center for Osteoporosis

Specialty

• Endocrinology and Bone Metabolism

Subspecialty

• Osteoporosis

Certification
Internal Medicine

Education
M.D., Harvard Medical School

State Licensure
Connecticut

Residency
Boston City Hospital (Harvard Service), Cushing VA Hospital, Boston VA Hospital

Awards

• Edwin B. Astwood Lecturer, Endocrine Society, 1983
• William F. Neuman Award, American Society for Bone and Mineral Research, 1986
• Class of 1947 Distinguished Professor, University of Wisconsin Medical School, 1988
• Honorary Doctor of Odontology, University of Umea, Sweden, 1990
• Bley Stein Visiting Professor, University Southern California, Los Angeles, 1991
• Distinguished Clinical Science Lecturer, Evans Research Day, Boston University 1992
• George W. Brackenridge Visiting Scholar, University of Texas Health Science Center at San Antonio, May 1995
• Plenary Lecturer, American Society for Bone and Mineral Research, 1996
• Wynd Visiting Professor, Endocrinology and Metabolism, University of Rochester, 1998
• Ernst Schering Research Foundation Lecturer, Berlin, 1999
• Shirley Hohl Service Award, American Society for Bone and Mineral Research, 2001
• George F. Thornton Award, CT Chapter, ACP, ASIM, 2001
• University of Connecticut Board of Directors Faculty Recognition Award 2003
• Louis V. Avioli Lectureship of American Society for Bone and Mineral Research 2003
• Kenneth Crispell Lecturer, University of Virginia, School of Medicine 2003
• Board of Trustees Distinguished Professor, University of Connecticut 2004
• Rochester General Hospital Association Teaching Fellow 2004
• Federick C. Bartter Visiting Professorship, The University of Texas Health Science Center 2005
• John G. Haddad, Jr. Memorial Lecture, University of Pennsylvania Medical Center 2005.

Selected Publications
From a list of 450 publications.

Ono K., Akatsu T., Kugai N., Pilbeam C.C., Raisz L.G. The effect of deletion of cyclooxygenase-2 prostaglandin receptor EP2 or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines. Bone 33:798-804, 2003.

Raisz, L.G. Homocysteine and osteoporotic fractures – culprit or bystander? NEJM 350:2089-2090, 2004.

Raisz, L.G. Bone Physiology Bone Cells, Modeling and Remodeling. In “Nutrition and Bone Health” M. F. Holick and B. Dawson-Hughes, eds., Humana Press, New Jersey 2004, 43-62.

Raisz, L.G. Screening for Osteoporosis. NEJM 353:164-171, 2005.

Raisz, L.G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115:3318-3325, 2005.

Kenny A.M., McGee D., Joseph C., Covault J., Abreu C., Raisz L.G. Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older men. Endocrine Res 31:285-293, 2006.

Raisz, L.G. Anabolic effect of prostaglandins. Clin Rev Bone Miner Metab;4:123-128, 2006.

Kenny A.M., Boxer R., Walsh S., Hager W.D., Raisz L.G. Femoral bone mineral density in patients with heart failure. Osteoporos Int 17:1420-1427, 2006.

Kenny A.M., Boxer R., Walsh S., Hager W.D., Raisz L.G. Femoral bone mineral density in patients with heart failure. Osteoporos Int 17:1420-1427, 2006.

View more publications, see Pubmed listing.

Research Interests

Clinical Research

• Study of the effect of estrogen, androgen and calcium on bone remodeling.
• The genetics of bone metabolism and the cellular mechanism of the action of estrogen.
   

Basic Science Research

• Role of prostaglandins and regulation of bone metabolism, in particular, with reference to the differential prostaglandin E2 and its receptors on bone formation and resorption.